Suggested by Destroyer Green Goblin is one of the most iconic Spiderman villains out there. The guy is fairly powerful and has obtained quite a few power ups over the years. You definitely don’t want to underestimate the guy. Still, he isn’t ready for Orochimaru’s fierce speed and regenerative abilities. Orochimaru will be able to overwhelm him with powerful ninjutsu at the ready. Goblin won’t be able to endure such an onslaught and will ultimately fall. Orochimaru wins.