It’s a battle of the Uchiha as Madara goes up against Sasuke. Sasuke has abilities that basically transcend those of the average ninja and we’e seen how deadly he can be in hand to hand combat. Madara is basically Sasuke’s equal in just about every category, but Sasuke has the edge when it comes to hand to hand combat. His speed simply would not be matched. Sasuke wins.

Update 12/3/2021 Ultimately I have to give this to Madara. As powerful as Sasuke is, I don’t think he could win this one alone. Madara wins.