Senku is a really good scientist, but that doesn’t mean that he’s ready for a fight at this level. Neo is incredibly powerful to the point where she was able to easily defeat Yang in a fight. Senku can’t think his way out of an impossible fight like this and Neo will be controlling the match from start to finish. Senku’s only logical choice here is to surrender because that’s 1 billion % his only chance to win. Neo wins.