Suggested by Sonic Squirrel Girl has some decent super strength and speed at her disposal but it’s nothing that Punisher hasn’t seen before. He’s been shown to fight at a high level as well taking guys like Captain America on in the past. He has a whole lot of guns and even got the Venom symbiote at one point. Squirrel Girl’s unpredictable fighting style won’t be enough to give her a decisive edge over the Punisher. He’ll still find a way to claim victory the way he always does. She would need at least one more critical ability to win here. Punisher wins.