Suggested by Sonic Nick Fury is a master strategist and he has a lot of crazy weapons and gadgets at his disposal. That being said, it will still not be quite enough to turn the tides in this battle. Mystique has obtained many power ups over the years including one that greatly amped up her power and speed. Throw that in with the fact that she is also as top notch agent and Fury has no advantages here. He would be quickly dispatched before being able to put up a proper fight. Mystique wins.