Suggested by Sonic Brainiac is one of Superman’s deadliest opponents. He can destroy whole worlds and has had many power ups over the years. The Brood are powerful little creatures that can easily overwhelm their opponents given enough time. That said, a single Brood is quite limited in what he can do. Meanwhile Brainiac has enough firepower to keep the entire Justice League at bay. A single stray shot would take the Brood out of the equation. Brainiac wins.