This is a pretty close fight and both of these guys are immensely powerful. One factor that tips the scales in Drax’s favor is his experience with flight and super speed. That should definitely come in handy here and the Hulk’s slight edge in physical strength won’t be able to overcome this. The Hulk may be the strongest there is..but he wasn’t strong enough. Drax The Destroyer wins.
DReager1.com 
What’s Drax’s best feat?
He’s traded blows with Thanos in the past, but Thanos is slightly weakened against him so take it lightly.
When Thanos was at Normal Power he one-shot Drax
I do think Thanos would crush Drax with ease.