The Sharktopus is reasonably tough, but he won’t be able to take Peach down for the count. Peach has her hand to hand experience from back in the day and her final smash can try to put Sharktopus to sleep. If all else fails, she can just run over Sharktopus with her Kart. The Sharktopus doesn’t really stand a chance here! Peach wins.
DReager1.com 
What the F–? Won’t Peach be profusely bleeding when it bites her leg?
It’ll need to catch her first and Peach has a lot of tools at her disposal.