“We Like Ike!” is Ike’s chant in the Super Smash Bros series and it is quite catchy, but that’s not enough to make him be strong enough to defeat Mewtwo. Mewtwo can use his telekinesis to wrench the sword away from Ike and that will be game over for the swordsman. Ike wouldn’t last a minute in close quarters combat against a foe as fast and strong as Mewtwo. A few good Shadow Balls should suffice to win the match for Mewtwo. Mewtwo wins.