Suggested by Destroyer This is a pretty intense fight as Supergirl and Wonder Woman are known as two of the strongest heroines in all of comics. That being said, I would give Supergirl the edge here. Her speed and power are just a little better than WW’s. Wonder Woman has the better hand to hand skills to combat that but she is still at a disadvantage. Supergirl is no slouch in that department after all and will manage to come out on top in the end. She has earned her spot as the strongest comic book heroine. Supergirl wins.