Suggested by Random Dio has his famous stand at the ready and he’s fairly formidable when it comes to strength as well. That being said, he can’t handle Goku. In Goku’s Super Saiyan Blue form he is basically invincible as his speed and power are amped up to an unbelievable level. Dio just wouldn’t be able to comprehend the speed at which Goku is moving. Goku wins.