Despero is one of the strongest DC villains out there. He has been shown to have enough power to take on the combined might of Superman, Shazam, and Wonder Woman in the past. That being said, at Superman’s best he will be more than a match for Despero. I’d give Superman the edge in strength and speed. His abilities really have no limits and that is exactly what makes Superman the best. He will always prove to be faster and stronger than his opponents. Superman wins.