Suggested by Sonic Samus is a strong fighter and certainly one of Nintendo’s most powerful protagonists. Her speed is at a high level and her Zero Laser is likely more powerful than any of Mega Man’s attacks. Mega Man does still have the edge physically though as we’ve seen what he is capable of in titles like Gigamix. He has more defense than Samus and what he lacks in martial art skills he makes up for in his large arsenal of abilities. Samus won’t be able to get past his skills and experience. Mega Man wins.