Suggested by Destroyer Howard has returned. He has been getting quite a few wins over the years and I believe this will end up being another one. Curious George is a really fun character who has been with us for generations, but he isn’t a fighter. Howard ultimately does have a gun so he at least stands a chance in a lot of fights. There just isn’t really much of anything that Curious George can do to try and make a comeback here. Howard will catch him and take him to the vet. Howard Aguello wins.
DReager1.com 
This is one battle Howard will lose without the right stuff, and not because George is a murder-monster, but rather possibly not knowing his own strength. Since this is applicable: https://www.newscientist.com/article/2138714-chimps-are-not-as-superhumanly-strong-as-we-thought-they-were/, Here’s the source for my opinion. Howard could still shoot George, though.
Yeah without equipment then this would get really rough for Howard. He does have his gun armed and ready though so that’ll cover him pretty well