Suggested by Anonymous Orochimaru has a lot of tricks up his sleeve and is always keeping things interesting with how he body hops all the time. In terms of pure power though there is absolutely no contest. Isshiki would easily clobber him with a few punches or an energy blast. Orochimaru shouldn’t be able to even detect the guy while he’s moving and will be quickly shut down. Isshiki Otsutsuki wins.