Suggested by Anonymous Isshiki Ōtsutsuki is a powerful fighter who even gave Naruto and Sasuke a run for their money. Kaguya did the same thing so this comes down to quite a few factors such as if young Naruto and Sasuke are stronger than the adult forms and if Isshiki is just stronger than Kaguya. Those are all debates in themselves but the reason I would put Isshiki above Kaguya is his mobility. He can move much quicker than she can and has displayed enough abilities needed to get past her defenses. He should win this fight. Isshiki Ōtsutsuki wins.
Suggested by Anonymous Isshiki Ōtsutsuki is a powerful fighter who even gave Naruto and Sasuke a run for their money. While Itachi is quite skilled and one of the most powerful fighters in the classic Naruto series, this is a level of power that his genjutsu would not be able to stop. Isshiki can even stop the Amaterasu in its tracks. Itachi may be able to come up with some plans to buy time but ultimately this is a match that Isshiki wins with brute strength. Isshiki Ōtsutsuki wins.
Suggested by Anonymous The Ten Tails is a powerful monster but it’s fair to say that he doesn’t have the speed or power needed to take down Isshiki. Isshiki can absorb jutsu and even manage to take on Naruto and Sasuke. Nothing that Ten Tails has at his disposal will be enough to even give him a fighting chance. This beast just can’t rely on power to get the job done here. Isshiki Otsutsuki wins.
Suggested by Anonymous Isshiki is back for one more fight. This time he gets to take down the 8 Tails real quick. Gyuki is good at regeneration and deception. He just knows how to pull one over the other fighters and that’s what makes him a dangerous threat. He may not be quite as strong as Isshiki but in a way he doesn’t have to be. He’ll lose this battle and learn from it. That’s good because no matter what tricks he can try to pull, this is a fight he can’t win. Isshiki Ōtsutsuki wins.
Suggested by Anonymous The Nine Tailed Fox may be able to posses Naruto’s body so he can use some of his power but he’s not operating at the same strength much like Omega Xis taking over Geo. I don’t see the Fox being able to dredge up enough power to take down Isshiki. It’s just not going to happen and with the guy as powerful and fast as he is, there is no room to make even a single mistake. The Nine Tailed Fox would need to try and take him out fast but with the guy’s regeneration that’s not in the cards. Isshiki Ōtsutsuki wins.
Suggested by Anonymous Isshiki Ōtsutsuki has already proven himself with quite a few wins. This one is naturally going to go in much the same way as Lucifer can’t really hope to take Isshiki down in a fair fight. Not only does this guy have the massive speed advantage but with one punch Isshiki should be able to take Lucifer down for the count. The guy just doesn’t have what it takes to defeat one of the premiere Boruto villains. Isshiki Ōtsutsuki wins.
Suggested by Anonymous Isshiki Ōtsutsuki is back once again and this time he’s taking on an immortal fighter. Immortality is one of those abilities that is only good if it’s paired with instant regeneration. Otherwise it can be more of a curse than anything else. Fortuna doesn’t have any abilities that would allow her to deal damage to Isshiki and isn’t able to dodge him so she will only last as long as her immortality keeps her in the game. Once the energy is spent up she will be down for the count. Isshiki Ōtsutsuki wins.
Suggested by Anonymous Isshiki Otsutsuki is a powerful foe and one of the strongest in all of Naruto without a doubt. That said, he definitely isn’t ready to deal with someone on this level. Naruto has his various super modes such as S06 and Baryon which will make quick work out of Isshiki. At this point in time it’s hard to see anyone defeating Naruto at his peak. The guy is just too crazy strong! Even Isshiki finally takes a loss here. Naruto wins.
Suggested by Anonymous Killer Bee may be someone who has a tailed beast but that’s just not going to be enough in this round. Isshiki Otsutsuki was able to speed blitz Naruto with ease who is considerably more powerful than Killer Bee. No matter how you slice it, that means that Bee is completely out of his league in this one. A few shots will take him down for the count. Isshiki Otsutsuki wins.
Suggested by Anonymous Hashirama was the first ever Hokage and yet he also ended up being one of the most powerful ones. The man was truly ahead of his time and certainly not someone who would go down too quickly. Still, Isshiki is much more powerful than Hashirama in virtually every area that matters. As a result it’s hard to see Hashirama having any avenues to victory. Isshiki Otsutsuki wins.