Suggested by Anonymous Sasuke is an Uchiha and as a result he has abilities that are far beyond those of the average fighter. That being said, would he really stand a chance in this fight? At his best Sasuke was certainly a fighter to be feared and even could give Naruto a run for his money. That said, it’s fair to say that Naruto has surpassed him as is the fate of all rivals and at the moment I don’t think Sasuke at his peak would have been enough to defeat Isshiki one on one. He would have to lose this round for now as Isshiki is just way too powerful. Isshiki Ōtsutsuki wins.