Suggested by Anonymous Isshiki Ōtsutsuki is a powerful fighter who even gave Naruto and Sasuke a run for their money. Kaguya did the same thing so this comes down to quite a few factors such as if young Naruto and Sasuke are stronger than the adult forms and if Isshiki is just stronger than Kaguya. Those are all debates in themselves but the reason I would put Isshiki above Kaguya is his mobility. He can move much quicker than she can and has displayed enough abilities needed to get past her defenses. He should win this fight. Isshiki Ōtsutsuki wins.
Suggested by Random Kaguya is a powerful Naruto villain and some may even say that she was the strongest of them all. Her sheer amount of chakra is unheard of and most abilities do not even affect her. Thanos has a lot of good attack options with the gems, but he will find it difficult trying to land a hit on Kaguya while she is dimension hopping. His durability also won’t be enough to endure her invincible spike attacks. This is one match that the Titan cannot win. Kaguya wins.
The Sage of Six Paths is a formidable opponent, but he definitely won’t be able to stop Kaguya. Kaguya can use her dimensional abilities to cause the Sage of Six Paths to fall into a vat of lava. There really isn’t all that much he can do to stop her since Kaguya is also faster and stronger than him. The Sage will have to take the loss. Kaguya wins.
Kaguya is back and she’s up against one of the strongest Naruto villains in existence. Controversially, I would say that Madara is the strongest villain in the series. Now, some may debate this, but I would just point to all of Madara’s feats. Speed, Endurance, Power…Madara has it all. Kaguya is impressive as well, but I just don’t see her holding her own in a fight against him in the end. It would be a solid fight, but Madara would emerge victorious from it. Madara wins.
Sakura has developed into a very powerful shinobi, but she won’t be able to defeat Kaguya. Kaguya makes her debut onto the blog at last and her abilities are not to be underestimated. Debatably, her physical abilities are on par with Sakura’s and her array of attacks is much larger. She should be able to evade Sakura’s blows while dealing out her own. A few minutes of such an onslaught should suffice. Kaguya wins.