Suggested by iKnowledge Isshiki Ōtsutsuki is an incredibly powerful fighter who was even able to go up against heavyweights like Naruto and Sasuke. Darkseid is powerful but he’s just not in the same league here. He will have a difficult time reacting to Isshiki’s blows and would be completely overwhelmed in hand to hand combat. It’s no wonder why Isshiki has become known as one of the strongest characters in his verse, his stats are just too good. Isshiki Ōtsutsuki wins.