Suggested by Ben 11 Akame and Sasuke are both very skilled swordfighters who rely on their speed to dominate their opponents. Akame may even be able to keep up with Sasuke to an extent but that’s really where she will hit her limits as a fighter. Sasuke has many big advantages over her such as his ninjutsu and Sharingan abilities. She would have to fight him while at a big disadvantage since he will continue to grow stronger and more accustomed to her moves as they fight. Ultimately she would fall. Sasuke wins.