Suggested by Destroyer Real Black Widow is one of the most notable spiders in the world but it’s not like they’re super strong. Madeline should have no problem knocking this creature out real quick. It doesn’t have a way to dodge her attacks and while one bite could help to turn the tides, I don’t think it could pull this off. Even if it could land a blow once every 10 matches or so, I believe the adrenaline of the fight would allow Madeline to win before succumbing. Madeline wins.
It will be painful, but Madeline will survive this due to Medicine. The Black Widow’s venom is nothing compared to other spiders.
Definitely, Madeline’s got this in the bag. If she has good aim maybe she can even throw her hat to trap it