Suggested by Destroyer Medusa can turn people into stone but that’ll be difficult against such a large opponent. Ghidorah is strong enough to break through that. Some incarnations also have a bow and arrow that she can use which can be dangerous but Ghidorah’s lasers will take care of that. Ultimately this is a fight that he can win through sheer power and Medusa is never particularly fast so she will have a tough time here. King Ghidorah wins.