Megaman has his handy Mega Buster, but he’s never faced an opponent quite like Sasuke! Sasuke is an Uchiha and was born to pwn. With one Chidori even the strongest of fighters fall before him! His speed is also pretty impressive, but at least Megaman put up a decent fight. Sasuke wins.
Update 8 7 2020 Megaman has the speed advantage here and Sasuke wouldn’t be able to keep up. Megaman wins.