Venom had a lot of muscle power back in the 90’s and he sized up well against heavy hitters like Doomsday and the Hulk. That being said, he wouldn’t be able to take Doomsday down. Doomsday’s defense is very solid (Despite what the New 52 would have you believe) and it will take a lot of hits to bring him down. Venom doesn’t have that kind of power and he can give Doomsday a good fight…but he’ll ultimately be defeated. Doomsday wins.