Suggested by Random Akame is a very fast fighter who relies on powerful strikes to eventually win a match or a precision stab to win in an instant. Neither option will work on Jiren as he is simply too quick to be hit. His durability is also on a whole other level so none of Akame’s attacks would have the slightest impact on him. Dragon Ball Super built him up to be one of the strongest beings in all of media and they did a very good job with this. There’s just no way he will lose here. Jiren wins.