Dante vs Trish
Suggested by Anonymous Trish is definitely a pretty strong ally. Her gun skills are first rate and she is pretty agile. Still, there’s never been any real doubt as to who would win in a fight between her and Dante. Dante is the main character of the series for a reason after all and Trish won’t be able to deal enough damage here. Dante can shake off almost any hit and her attacks won’t be any exception. Nobody’s taking this guy down just yet. Dante wins.