Suggested by Anonymous Isshiki Ōtsutsuki returns once more for yet another win. None of these guys seem to be a match for him at present and it’s no surprise. Isshiki is one of the strongest fighters in his verse for good reason. Dean would have to try really hard to keep this guy down and it’s just not happening. There’s nothing in the Supernatural verse that could do the trick so that means Dean is out of options here. Isshiki Ōtsutsuki wins.