Suggested by Anonymous Hashirama was the first ever Hokage and yet he also ended up being one of the most powerful ones. The man was truly ahead of his time and certainly not someone who would go down too quickly. Still, Isshiki is much more powerful than Hashirama in virtually every area that matters. As a result it’s hard to see Hashirama having any avenues to victory. Isshiki Otsutsuki wins.