Suggested by Anonymous Hashirama was the first ever Hokage and yet he also ended up being one of the most powerful ones. The man was truly ahead of his time and certainly not someone who would go down too quickly. Still, Isshiki is much more powerful than Hashirama in virtually every area that matters. As a result it’s hard to see Hashirama having any avenues to victory. Isshiki Otsutsuki wins.
This is a fierce battle of legends since Minato and Hashirama are both very powerful. Hashirama has several ninjutsu of incredible size and power, which would prove to be tough to stop. That being said, he may have gotten a lot of hype and a sound reputation, but a good deal of it occurs from off screen feats. Minato is more of a speed fighter and he has a lot of powerful abilities as well. His teleporting jutsu can turn the tides in battle and he is able to augment his physical strength to top things off. Hashirama will not be able to defeat him, but it would be a very close fight. Minato wins.
Hiruzen Sarutobi is the Third Hokage of the Leaf and while he can definitely fight at a high level; he will always be in the shadow of Hashirama. Hashirama was the original Hokage and many still consider him to be the strongest one of all time. His hand to hand skills are light years ahead of Hiruzen Sarutobi’s and Hashirama is also a great deal faster. Hashirama wins.