It’s a battle between these two Rogers. Roger Smith pilots the incredibly powerful Big O and he is not a bad hand to hand fighter if necessary. Roger (American Dad) is a mean alien who wouldn’t hesitate to bully someone, but there’s nothing he can do against a robot. He can try to delay the inevitable by retreating to his home, but he will ultimately be hunted down. Roger Smith will bring him in dead or alive, so the other Roger just needs to decide which status is preferable. Roger Smith wins.