Astro Boy and Mega Man used to be big time rivals. They were so intense it was almost on par with the Sonic vs Mario matchup of today. It’s hard to blame fans because Astro Boy and Mega Man are very similar. They are both kids who became robots to defend the world. There creators look very similar. They both had the other professor betray them. Both of them have mega busters. Mega Man would win here due to the fact that he has obtained the powers of over 64 robots. Mega Man wins.