Lazerman has the disruption beam that he can use to shoot Spyke. Spyke just isn’t strong enough to take on the likes of Lazerman. Lazerman just has too many Lazers. Lazerman wins.
Cosmoman has some cosmic powers that he can use to blow away Spyke. Spyke just can’t handle the power. Cosmoman is too powerful for him. Cosmoman wins.
Mario has super saiyan mode that he can use to shoot energy beams. With them he can quickly defeat Spyke. Spyke just isn’t tough enough to take on this power. Mario wins.