Suggested by Anonymous Tobirama never got as much hype as the other Hokages but the guy does pack a punch. He would have to be one of the stronger Naruto characters. That doesn’t mean he’s ready for the next gen though and he would ultimately fall fairly quick against this guy. Isshiki is just in a completely different league. Isshiki Otsutsuki wins.
Suggested by Sonic Tobirama is one of the original Hokages so his power level is considerable. That said, as strong as he is the guy is still outmatched by Kabuto. Kabuto was already powerful before he absorbed Orochimaru’s abilities. After that the guy got even more broken to the point where he is one of the toughest fighters in the verse. Senju would not be able to keep up. Kabuto wins.
Tobirama Senju is back and he’s up against Hiruzen! Hiruzen may be a pretty tough Hokage, but he lacks Tobirama’s physical abilities. Tobirama would be able to overwhelm Hiruzen with various ninjutsu as he takes the time to hit Hiruzen with a devastating punch. Hiruzen would not be able to cope with Tobirama’s speed and that will be the end of the road for him. Tobirama Senju wins.
Infernape is a pretty powerful pokemon who always manages to stay calm and collected on the battlefield. Tobirama Senju may not have been the strongest hokage out there, but his speed is still considerable. His hand to hand abilities are also intense and he tops it off with some good water ninjutsu. Tobirama Senju wins.