Harry Callahan may be a tough customer but he hasn’t been through quite as much as Fuuko. She really survived for many years on her own and was able to gain great strength. Harry would not be able to tag her even with his gun at this point and she definitely has the edge in overall fighting ability. Harry just wouldn’t have many options to use against her at this point and couldn’t survive a single hit. Fuuko wins.
Harry Callahan vs Fuuko