Alucard (Hellsing) vs Frieza
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Suggested by Random Alucard may essentially be immortal but that won’t be enough to slow Frieza down. Frieza is the destroyer of worlds. He can end the fight with a piercing death beam that wouldn’t leave a shred of Alucard left. No amount of regeneration would save him from such an attack and that’s why you need some good offensive abilities to match your defensive ones. Frieza wins.